Extreme Polygenicity of Complex Traits Is Explained by Negative Selection

Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans

Recent studies in population of European ancestry have shown that 30% ~ 50% of heritability for human complex traits such as height and body mass index, and common diseases such as schizophrenia and rheumatoid arthritis, can be captured by common SNPs and that genetic variation attributed to chromosomes are in proportion to their length. Using genome-wide estimation and partitioning approaches,...

Pdf extreme programming explained

Extreme Programming XP nominates coding as the key activity throughout a. have spent the last fifteen years just trying to explain to other people what he.Praise for Extreme Programming Explained, Second Edition. Extreme Programming Explained is the work of a talented and passionate craftsman. Kent Beck.Extreme Programming turns the conventional software process sideways. Explain or demonstrate...

Extreme programming explained - embrace change

I almost didn’t write this review. Extreme Programming (XP) and the whole agile software development movement are somewhat controversial, especially around Rational where the RUP is the party line. I certainly didn’t want to make a career-limiting move by advocating a software development methodology contrary to the one embraced by Rational! ☺ The perception (at least in some circles) seems to ...

Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

Is the atherosclerotic risk of extreme dipping in youth partly explained by exaggerated morning surge?

Is the Atherosclerotic Risk of Extreme Dipping in Youth Partly Explained by Exaggerated Morning Surge? To the Editor: I have read the article by Viera et al demonstrating that disrupted circadian rhythm of blood pressure (BP) in youth was a predictor of coronary calcium levels in younger adults. The study is of great interest because, although an association between normotensive nondippers and ...